agronaukaАграрная наука Евро-Северо-ВостокаAgricultural Science Euro-North-East2072-90812500-1396FARC North-East10.30766/2072-9081.2025.26.4.737-748agronauka-2143Research ArticleОБЗОРНЫЕ СТАТЬИREVIEWПерспективы использования кустарников Европейской части России в животноводстве (обзор)Prospects for the use of shrubs of the European part of Russia in animal husbandry (review)https://orcid.org/0000-0003-1111-8293ИнчаговаК. С.InchagovaK. S.

Инчагова Ксения Сергеевна, кандидат биол. наук, научный сотрудник лаборатории селекционно-генетических исследований в животноводстве,

ул. 9 Января д. 29, г. Оренбург, Оренбургская область, 460000

Kseniуa S. Inchagova, PhD in Biological Science, researcher, the Laboratory of Breeding and Genetic Research in Animal Husbandry,

29, 9 Janvarya St., Orenburg, Orenburg Region, 460000

fncbst@mail.ruhttps://orcid.org/0000-0002-9377-7673ВершининаИ. А.VershininaI. A.

Вершинина Ирина Александровна, кандидат биол. наук, научный сотрудник отдела технологии зерновых и кормовых культур,

ул. 9 Января д. 29, г. Оренбург, Оренбургская область, 460000

Irina A. Vershinina, PhD in Biological Science, researcher, the Department of Grain and Forage Crops Technology, 

29, 9 Janvarya St., Orenburg, Orenburg Region, 460000

gavrish.irina.ogu@gmail.comФГБНУ «Федеральный научный центр биологических систем и агротехнологий Российской академии наук»РоссияFederal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of SciencesRussian Federation202530082025264737748Copyright © Инчагова К.С., Вершинина И.А., 20252025Инчагова К.С., Вершинина И.А.Inchagova K.S., Vershinina I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.agronauka-sv.ru/jour/article/view/2143

В обзоре представлены сведения о кустарниках родов Crataegus L., Ephedra L., Frangula L., Prunus L., Rhamnus L., Rubus L. различных семейств (Rosaceae, Ephedraceae, Rhamnaceae), традиционно произрастающих в Европейской части России. Данные растения широко известны, как обладающие потенциалом в качестве перспективных источников биологически активных соединений классов терпеноидов, флавоноидов, алкалоидов и антраценпроизводных. Анализ 80 источников научной литературы направлен на поиск новых подходов в профилактике и лечении заболеваний сельскохозяйственных животных, основанных на безопасных и эффективных принципах, так как применение синтезированных лекарственных препаратов сопряжено с развитием нежелательных эффектов, а в случае с антибиотиками – устойчивости бактерий. В этой связи применение природных источников биологически активных веществ имеет преимущества по сравнению с синтезированными препаратами, в таких аспектах, как минимизация побочных эффектов, эффективность и экономическая выгода. В настоящем обзоре проведен анализ значимости растений указанных родов и семейств для животноводства. Представлена информация о содержании биологически активных веществ в этих растениях и их фармакологических свойствах, практическом применении и потенциале для использования в сельском хозяйстве как альтернативы фармацевтическим препаратам, обсуждаются возможности будущих исследований в этом аспекте.

The review presents information about shrubs of the genera Crataegus L., Ephedra L., Frangula L., Prunus L., Rhamnus L., Rubus L. of various families (Rosaceae, Ephedraceae, Rhamnaceae), traditionally growing in the European part of Russia. These plants have potential as promising sources of biologically active compounds of the classes of terpenoids, flavonoids, alkaloids and anthracene derivatives. The analysis of 80 sources of scientific literature is aimed at finding new approaches to the prevention and treatment of diseases of farm animals, based on safe and effective principles, since the use of synthesized drugs is associated with the development of undesirable effects, and in the case of antibiotics - bacterial resistance. In this regard, the use of natural sources of biologically active substances has advantages over synthesized drugs in such aspects as minimization of side effects, efficiency and economic benefit. This review analyzes the importance of plants of the specified genera and families for animal husbandry. Information on the content of biologically active substances, pharmacological properties, practical application and potential for use in agriculture as an alternative to pharmaceuticals is presented, and the possibilities for future research in this aspect are discussed.

CrataegusEphedraFrangulaPrunusRhamnusRubusсельское хозяйствокормлениелекарственные растенияCrataegusEphedraFrangulaPrunusRhamnusRubusagriculturefeedingmedicinal plantsРабота выполнена при финансовой поддержке Минобрнауки РФ в рамках Государственного задания ФГБНУ «Федеральный научный центр биологических систем и агротехнологий Российской академии наук» (тема № FNWZ-2025-0003).The research was carried out under the financial support of the Ministry of Science and Higher Education of the Russian Federation within the state assignment of the Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences (theme No. № FNWZ-2025-0003).ReferencesElkholly D. A., Brodbelt D. C., Church D. B., Pelligand L., Mwacalimba K., Wright A. K., O'Neill D. G. Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK. Frontiers in Veterinary Science. 2020;7:515. DOI: https://doi.org/10.3389/fvets.2020.00515Elkholly D. A., Brodbelt D. C., Church D. B., Pelligand L., Mwacalimba K., Wright A. K., O'Neill D. G. Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK. Frontiers in Veterinary Science. 2020;7:515. DOI: https://doi.org/10.3389/fvets.2020.00515Noor F., Tahir ul Qamar M., Ashfaq U. A., Albutti A., Alwashmi A. S., Aljasir M. A. Network pharmacology approach for medicinal plants: review and assessment. Pharmaceuticals. 2022;15(5):572. DOI: https://doi.org/10.3390/ph15050572Noor F., Tahir ul Qamar M., Ashfaq U. A., Albutti A., Alwashmi A. S., Aljasir M. A. Network pharmacology approach for medicinal plants: review and assessment. Pharmaceuticals. 2022;15(5):572. DOI: https://doi.org/10.3390/ph15050572Abdallah E. M., Alhatlani B. Y., de Paula Menezes R., Martins C. H. G. Back to Nature: Medicinal plants as promising sources for antibacterial drugs in the post-antibiotic era. Plants. 2023;12(17):3077. DOI: https://doi.org/10.3390/plants12173077Abdallah E. M., Alhatlani B. Y., de Paula Menezes R., Martins C. H. G. Back to Nature: Medicinal plants as promising sources for antibacterial drugs in the post-antibiotic era. Plants. 2023;12(17):3077. DOI: https://doi.org/10.3390/plants12173077Cui M., Cheng L., Zhou Z., Zhu Z., Liu Y., Li C. et al. Traditional uses, phytochemistry, pharmacology, and safety concerns of hawthorn (Crataegus genus): A comprehensive review. Journal of ethnopharmacology. 2024;319(2):117229. DOI: https://doi.org/10.1016/j.jep.2023.117229Cui M., Cheng L., Zhou Z., Zhu Z., Liu Y., Li C. et al. Traditional uses, phytochemistry, pharmacology, and safety concerns of hawthorn (Crataegus genus): A comprehensive review. Journal of ethnopharmacology. 2024;319(2):117229. DOI: https://doi.org/10.1016/j.jep.2023.117229Bussmann R. W., Paniagua-Zambrana N. Y., Kikvidze Z., Batsatsashvili K., Khutsishvili M., Maisaia I. et al. Frangula alnus Miller, Rhamnus cathartica L., Rhamnus imeretina Booth, Petz., G. Kirchn. Rhamnaceae. In: Bussmann, R.W. (eds) Ethnobotany of the Caucasus. Ethnobotany of Mountain Regions. Springer, Cham, 2025. pp. 1–16. DOI: https://doi.org/10.1007/978-3-319-50009-6_319-1Bussmann R. W., Paniagua-Zambrana N. Y., Kikvidze Z., Batsatsashvili K., Khutsishvili M., Maisaia I. et al. Frangula alnus Miller, Rhamnus cathartica L., Rhamnus imeretina Booth, Petz., G. Kirchn. Rhamnaceae. In: Bussmann, R.W. (eds) Ethnobotany of the Caucasus. Ethnobotany of Mountain Regions. Springer, Cham, 2025. pp. 1–16. DOI: https://doi.org/10.1007/978-3-319-50009-6_319-1Lee T. D., Eisenhaure S. E., Gaudreau I. P. Pre-logging treatment of invasive glossy buckthorn (Frangula alnus Mill.) promotes regeneration of eastern white pine (Pinus strobus L.). Forests. 2017;8(1):16. DOI: https://doi.org/10.3390/f8010016Lee T. D., Eisenhaure S. E., Gaudreau I. P. Pre-logging treatment of invasive glossy buckthorn (Frangula alnus Mill.) promotes regeneration of eastern white pine (Pinus strobus L.). Forests. 2017;8(1):16. DOI: https://doi.org/10.3390/f8010016Đukanović S., Cvetković S., Lončarević B., Lješević M., Nikolić B., Simin N. et al. Antistaphylococcal and biofilm inhibitory activities of Frangula alnus bark ethyl-acetate extract. Industrial Crops and Products. 2020;158:113013. DOI: https://doi.org/10.1016/j.indcrop.2020.113013Đukanović S., Cvetković S., Lončarević B., Lješević M., Nikolić B., Simin N. et al. Antistaphylococcal and biofilm inhibitory activities of Frangula alnus bark ethyl-acetate extract. Industrial Crops and Products. 2020;158:113013. DOI: https://doi.org/10.1016/j.indcrop.2020.113013Nejabatdoust A., Daemi H. B., Salehzadeh A. Comparing of Effects of Hydro-alcoholic, Ethanolic, and Methanolic Extracts of the Frangula alnus: Chemical Composition, Antimicrobial, and Synergism. Journal of Genetic Resources. 2020;6(1):20–33. DOI: https://doi.org/10.22080/jgr.2020.2538Nejabatdoust A., Daemi H. B., Salehzadeh A. Comparing of Effects of Hydro-alcoholic, Ethanolic, and Methanolic Extracts of the Frangula alnus: Chemical Composition, Antimicrobial, and Synergism. Journal of Genetic Resources. 2020;6(1):20–33. DOI: https://doi.org/10.22080/jgr.2020.2538Kremer D., Kosalec I., Locatelli M., Epifano F., Genovese S., Carlucci G., Končić M. Z. Anthraquinone profiles, antioxidant and antimicrobial properties of Frangula rupestris (Scop.) Schur and Frangula alnus Mill. Bark. Food Chemistry. 2012;131(4):1174–1180. DOI: https://doi.org/10.1016/j.foodchem.2011.09.094Kremer D., Kosalec I., Locatelli M., Epifano F., Genovese S., Carlucci G., Končić M. Z. Anthraquinone profiles, antioxidant and antimicrobial properties of Frangula rupestris (Scop.) Schur and Frangula alnus Mill. Bark. Food Chemistry. 2012;131(4):1174–1180. DOI: https://doi.org/10.1016/j.foodchem.2011.09.094Brkanac S. R., Gerić M., Gajski G., Vujčić V., Garaj-Vrhovac V., Kremer D., Domijan A. M. Toxicity and antioxidant capacity of Frangula alnus Mill. bark and its active component emodin. Regulatory Toxicology and Pharmacology. 2015;73(3):923–929. DOI: https://doi.org/10.1016/j.yrtph.2015.09.025Brkanac S. R., Gerić M., Gajski G., Vujčić V., Garaj-Vrhovac V., Kremer D., Domijan A. M. Toxicity and antioxidant capacity of Frangula alnus Mill. bark and its active component emodin. Regulatory Toxicology and Pharmacology. 2015;73(3):923–929. DOI: https://doi.org/10.1016/j.yrtph.2015.09.025García-González R., Giráldez F. J., Mantecón A. R., González J. S., López S. Effects of rhubarb (Rheum spp.) and frangula (Frangula alnus) on intake, digestibility and ruminal fermentation of different diets and feedstuffs by sheep. Animal Feed Science and Technology. 2012;176(1-4):131–139. DOI: https://doi.org/10.1016/j.anifeedsci.2012.07.016García-González R., Giráldez F. J., Mantecón A. R., González J. S., López S. Effects of rhubarb (Rheum spp.) and frangula (Frangula alnus) on intake, digestibility and ruminal fermentation of different diets and feedstuffs by sheep. Animal Feed Science and Technology. 2012;176(1-4):131–139. DOI: https://doi.org/10.1016/j.anifeedsci.2012.07.016García-González R., López S., Fernández M., González J. S. Dose–response effects of Rheum officinale root and Frangula alnus bark on ruminal methane production in vitro. Animal Feed Science and Technology. 2008;145(1-4):319–334. DOI: https://doi.org/10.1016/j.anifeedsci.2007.05.040García-González R., López S., Fernández M., González J. S. Dose–response effects of Rheum officinale root and Frangula alnus bark on ruminal methane production in vitro. Animal Feed Science and Technology. 2008;145(1-4):319–334. DOI: https://doi.org/10.1016/j.anifeedsci.2007.05.040Nota G., Svensk M., Barberis D., Frund D., Pagani R., Pittarello M. et al. Foraging behavior of Highland cattle in silvopastoral systems in the Alps. Agroforestry System. 2024;98:491–505. DOI: https://doi.org/10.1007/s10457-023-00926-zNota G., Svensk M., Barberis D., Frund D., Pagani R., Pittarello M. et al. Foraging behavior of Highland cattle in silvopastoral systems in the Alps. Agroforestry System. 2024;98:491–505. DOI: https://doi.org/10.1007/s10457-023-00926-zLabokas J., Karpaviciene B. Development of a Methodology for Maintenance of Medicinal Plant Genetic Reserve Sites: A Case Study for Lithuania. Plants. 2021;10(4):658. DOI: https://doi.org/10.3390/plants10040658Labokas J., Karpaviciene B. Development of a Methodology for Maintenance of Medicinal Plant Genetic Reserve Sites: A Case Study for Lithuania. Plants. 2021;10(4):658. DOI: https://doi.org/10.3390/plants10040658Klich D. Influence of primitive Biłgoraj horses on the glossy buckthorn (Frangula alnus)-dominated understory in a mixed coniferous forest. Acta Oecologica. 2018;87:8–12. DOI: https://doi.org/10.1016/j.actao.2018.01.002Klich D. Influence of primitive Biłgoraj horses on the glossy buckthorn (Frangula alnus)-dominated understory in a mixed coniferous forest. Acta Oecologica. 2018;87:8–12. DOI: https://doi.org/10.1016/j.actao.2018.01.002Kurylo J. S., Knight K. S., Stewart J. R., Endress A. G. Rhamnus cathartica: Native and naturalized distribution and habitat preferences. The Journal of the Torrey Botanical Society. 2007;134(3):420–430. DOI: https://doi.org/10.3159/1095-5674(2007)134[420:RCNAND]2.0.CO;2Kurylo J. S., Knight K. S., Stewart J. R., Endress A. G. Rhamnus cathartica: Native and naturalized distribution and habitat preferences. The Journal of the Torrey Botanical Society. 2007;134(3):420–430. DOI: https://doi.org/10.3159/1095-5674(2007)134[420:RCNAND]2.0.CO;2Hamed M. M., Refahy L. A., Abdel-Aziz M. S. Evaluation of Antimicrobial Activity of Some Compounds Isolated from Rhamnus cathartica L. Oriental Journal of Chemistry. 2015;31(2):1133–1140. DOI: https://doi.org/10.13005/ojc/310266Hamed M. M., Refahy L. A., Abdel-Aziz M. S. Evaluation of Antimicrobial Activity of Some Compounds Isolated from Rhamnus cathartica L. Oriental Journal of Chemistry. 2015;31(2):1133–1140. DOI: https://doi.org/10.13005/ojc/310266Ibrahim B., Reis A., Arin U. E., Muhammed M. T., Onem E. An Evaluation of the Anti-QS Activity and Virulence Factors Production Potential of Rhamnus cathartica L. against Some Gram-Positive and Gram-Negative Bacteria. Medicine and Pharmacology. 2023 (Preprints). DOI: https://doi.org/10.20944/preprints202312.1822.v1Ibrahim B., Reis A., Arin U. E., Muhammed M. T., Onem E. An Evaluation of the Anti-QS Activity and Virulence Factors Production Potential of Rhamnus cathartica L. against Some Gram-Positive and Gram-Negative Bacteria. Medicine and Pharmacology. 2023 (Preprints). DOI: https://doi.org/10.20944/preprints202312.1822.v1Hedayati P., Chabra A., Parandin F., Rahimi Esboei B. Anti-leishmaniasis activity of Rhamnus cathatica on amastigote stages of Leishmania major. International Journal of Molecular and Clinical Microbiology. 2023;13(1):1802–1809. DOI: https://doi.org/10.22034/IJMCM.2023.703699Hedayati P., Chabra A., Parandin F., Rahimi Esboei B. Anti-leishmaniasis activity of Rhamnus cathatica on amastigote stages of Leishmania major. International Journal of Molecular and Clinical Microbiology. 2023;13(1):1802–1809. DOI: https://doi.org/10.22034/IJMCM.2023.703699Bayat F., Haghi A. M., Nateghpour M., Rahimi-Esboei B., Foroushani A. R. et al. Cytotoxiity and AntiPlasmodium berghei Activity of Emodin Loaded Nanoemulsion. Iranian Journal of Parasitology. 2022;17(3):339–348. DOI: https://doi.org/10.18502/ijpa.v17i3.10624Bayat F., Haghi A. M., Nateghpour M., Rahimi-Esboei B., Foroushani A. R. et al. Cytotoxiity and AntiPlasmodium berghei Activity of Emodin Loaded Nanoemulsion. Iranian Journal of Parasitology. 2022;17(3):339–348. DOI: https://doi.org/10.18502/ijpa.v17i3.10624Lichtensteiger C. A., Johnston N. A., Beasley V. R. Rhamnus cathartica (Buckthorn) Hepatocellular Toxicity in Mice. Toxicologic pathology. 1997;25(5):449–452. DOI: https://doi.org/10.1177/019262339702500503Lichtensteiger C. A., Johnston N. A., Beasley V. R. Rhamnus cathartica (Buckthorn) Hepatocellular Toxicity in Mice. Toxicologic pathology. 1997;25(5):449–452. DOI: https://doi.org/10.1177/019262339702500503Brenes R., Nguyen L. M. N., Miller D. L., Rohde M. L. Hepatocellular toxicity of the metabolite emodin produced by the common buckthorn (Rhamnus cathartica) in green frog (Lithobates clamitans) tadpoles. Journal of Wildlife Diseases. 2022;58(2):341–347. DOI: https://doi.org/10.7589/JWD-D-21-00040Brenes R., Nguyen L. M. N., Miller D. L., Rohde M. L. Hepatocellular toxicity of the metabolite emodin produced by the common buckthorn (Rhamnus cathartica) in green frog (Lithobates clamitans) tadpoles. Journal of Wildlife Diseases. 2022;58(2):341–347. DOI: https://doi.org/10.7589/JWD-D-21-00040Rhamnus cathartica. Reactions Weekly. 2011;1347:34. DOI: https://doi.org/10.2165/00128415-201113470-00113Rhamnus cathartica. Reactions Weekly. 2011;1347:34. DOI: https://doi.org/10.2165/00128415-201113470-00113Popescu I., Caudullo G. Prunus spinosa in Europe: distribution, habitat, usage and threats. 2016. In book: European Atlas of Forest Tree Species. Editors: San-Miguel-Ayanz J., de Rigo D., Caudullo G., Durrant T. H., Mauri A. Publisher: Publication Office of the European Union, Luxembourg, 2016. pp. e018f4e+. URL: https://www.researchgate.net/publication/299471144_Prunus_spinosa_in_Europe_distribution_habitat_usage_and_threatsPopescu I., Caudullo G. Prunus spinosa in Europe: distribution, habitat, usage and threats. 2016. In book: European Atlas of Forest Tree Species. Editors: San-Miguel-Ayanz J., de Rigo D., Caudullo G., Durrant T. H., Mauri A. Publisher: Publication Office of the European Union, Luxembourg, 2016. pp. e018f4e+. URL: https://www.researchgate.net/publication/299471144_Prunus_spinosa_in_Europe_distribution_habitat_usage_and_threatsBei M. F., Apahidean A. I., Budau R., Rosan C. A., Popovici R., Memete A. R. et al. An Overview of the Phytochemical Composition of Different Organs of Prunus spinosa L., Their Health Benefits and Application in Food Industry. Horticulturae. 2024;10(1):29. DOI: https://doi.org/10.3390/horticulturae10010029Bei M. F., Apahidean A. I., Budau R., Rosan C. A., Popovici R., Memete A. R. et al. An Overview of the Phytochemical Composition of Different Organs of Prunus spinosa L., Their Health Benefits and Application in Food Industry. Horticulturae. 2024;10(1):29. DOI: https://doi.org/10.3390/horticulturae10010029Marcetic M., Samardzic S., Ilic T., Bozic D. D., Vidovic B. Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits. Foods. 2022;11(20):3289. DOI: https://doi.org/10.3390/foods11203289Marcetic M., Samardzic S., Ilic T., Bozic D. D., Vidovic B. Phenolic Composition, Antioxidant, Anti-Enzymatic, Antimicrobial and Prebiotic Properties of Prunus spinosa L. Fruits. Foods. 2022;11(20):3289. DOI: https://doi.org/10.3390/foods11203289Marchelak A., Owczarek A., Matczak M., Pawlak A., Kolodziejczyk-Czepas J., Nowak P., Olszewska M. A. Bioactivity Potential of Prunus spinosa L. Flower Extracts: Phytochemical Profiling, Cellular Safety, Pro-inflammatory Enzymes Inhibition and Protective Effects Against Oxidative Stress In Vitro. Frontiers in Pharmacology. 2017;8:680. DOI: https://doi.org/10.3389/fphar.2017.00680Marchelak A., Owczarek A., Matczak M., Pawlak A., Kolodziejczyk-Czepas J., Nowak P., Olszewska M. A. Bioactivity Potential of Prunus spinosa L. Flower Extracts: Phytochemical Profiling, Cellular Safety, Pro-inflammatory Enzymes Inhibition and Protective Effects Against Oxidative Stress In Vitro. Frontiers in Pharmacology. 2017;8:680. DOI: https://doi.org/10.3389/fphar.2017.00680Kumarasamy Y., Cox P. J., Jaspars M., Nahar L., Sarker S. D. Comparative studies on biological activities of Prunus padus and P. spinose. Fitoterapia. 2004;75(1):77–80. DOI: https://doi.org/10.1016/j.fitote.2003.08.011Kumarasamy Y., Cox P. J., Jaspars M., Nahar L., Sarker S. D. Comparative studies on biological activities of Prunus padus and P. spinose. Fitoterapia. 2004;75(1):77–80. DOI: https://doi.org/10.1016/j.fitote.2003.08.011Rodriguez R., Lasheras B., Cenarruzabeitia E. Pharmacological Activity of Prunus spinosa on Isolated Tissue Preparations. Planta Medica. 1986;52(4):256–259. DOI: https://doi.org/10.1055/s-2007-969145Rodriguez R., Lasheras B., Cenarruzabeitia E. Pharmacological Activity of Prunus spinosa on Isolated Tissue Preparations. Planta Medica. 1986;52(4):256–259. DOI: https://doi.org/10.1055/s-2007-969145Sabatini L., Fraternale D., Di Giacomo B., Mari M., Albertini M. C., Gordillo B. et al. Chemical composition, antioxidant, antimicrobial and anti-inflammatory activity of Prunus spinosa L. fruit ethanol extract. Journal of Functional Foods. 2020;67:103885. DOI: https://doi.org/10.1016/j.jff.2020.103885Sabatini L., Fraternale D., Di Giacomo B., Mari M., Albertini M. C., Gordillo B. et al. Chemical composition, antioxidant, antimicrobial and anti-inflammatory activity of Prunus spinosa L. fruit ethanol extract. Journal of Functional Foods. 2020;67:103885. DOI: https://doi.org/10.1016/j.jff.2020.103885Velickovic I., Zizak Z., Rajcevic N., Ivanov M., Sokovic M., Marin P. D., Grujic S. Prunus spinosa L. leaf extracts: polyphenol profile and bioactivities. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2021;49(1):12137. DOI: https://doi.org/10.15835/NBHA49112137Velickovic I., Zizak Z., Rajcevic N., Ivanov M., Sokovic M., Marin P. D., Grujic S. Prunus spinosa L. leaf extracts: polyphenol profile and bioactivities. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2021;49(1):12137. DOI: https://doi.org/10.15835/NBHA49112137Velickovic I., Zizak Z., Rajcevic N., Ivanov M., Sokovic M., Marin P. D., Grujic S. Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts. Archives of Biological Sciences. 2020;72(1):105–115. DOI: https://doi.org/10.2298/ABS191217004VVelickovic I., Zizak Z., Rajcevic N., Ivanov M., Sokovic M., Marin P. D., Grujic S. Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts. Archives of Biological Sciences. 2020;72(1):105–115. DOI: https://doi.org/10.2298/ABS191217004VFacciolati V., Zarek M., Błońska E., Lasota J., Orman O., Ciach M. To be browsed or not to be browsed: differences in nutritional characteristics of blackthorn Prunus spinosa subject to the long-term pressure of herbivores. bioRxiv. 2024. (Preprint). DOI: https://doi.org/10.1101/2024.04.04.588043Facciolati V., Zarek M., Błońska E., Lasota J., Orman O., Ciach M. To be browsed or not to be browsed: differences in nutritional characteristics of blackthorn Prunus spinosa subject to the long-term pressure of herbivores. bioRxiv. 2024. (Preprint). DOI: https://doi.org/10.1101/2024.04.04.588043Smit C., Bakker E. S., Apol M. E. F., Olff H. Effects of cattle and rabbit grazing on clonal expansion of spiny shrubs in wood-pastures. Basic and Applied Ecology. 2010;11(8):685–692. DOI: https://doi.org/10.1016/j.baae.2010.08.010Smit C., Bakker E. S., Apol M. E. F., Olff H. Effects of cattle and rabbit grazing on clonal expansion of spiny shrubs in wood-pastures. Basic and Applied Ecology. 2010;11(8):685–692. DOI: https://doi.org/10.1016/j.baae.2010.08.010Ashton N. M., Doles J. Plant Thorn Synovitis Caused by Prunus Spinosa (Blackthorn) Penetration in 35 Horses. Equine Veterinary Journal.. 2015;S47:17. DOI: https://doi.org/10.1111/evj.12486_38Ashton N. M., Doles J. Plant Thorn Synovitis Caused by Prunus Spinosa (Blackthorn) Penetration in 35 Horses. Equine Veterinary Journal.. 2015;S47:17. DOI: https://doi.org/10.1111/evj.12486_38Bullitta S., Re G. A., Manunta M. D. I., Piluzza G. Traditional knowledge about plant, animal, and mineral-based remedies to treat cattle, pigs, horses, and other domestic animals in the Mediterranean island of Sardinia. Journal of Ethnobiology and Ethnomedicine. 2018;14:50. DOI: https://doi.org/10.1186/s13002-018-0250-7Bullitta S., Re G. A., Manunta M. D. I., Piluzza G. Traditional knowledge about plant, animal, and mineral-based remedies to treat cattle, pigs, horses, and other domestic animals in the Mediterranean island of Sardinia. Journal of Ethnobiology and Ethnomedicine. 2018;14:50. DOI: https://doi.org/10.1186/s13002-018-0250-7Sagaradze V. A., Babaeva E. Y., Kalenikova E. I., Trusov N. A., Peshchanskaya E. V. Quantitative Anatomical Characteristics of the Leaf Blades of the Several Species of Crataegus L. Drug development & registration. 2021;10(4):138–146. (In Russ.). DOI: https://doi.org/10.33380/2305-2066-2021-10-4-138-146 EDN: YXIKQJSagaradze V. A., Babaeva E. Y., Kalenikova E. I., Trusov N. A., Peshchanskaya E. V. Quantitative Anatomical Characteristics of the Leaf Blades of the Several Species of Crataegus L. Drug development & registration. 2021;10(4):138–146. (In Russ.). DOI: https://doi.org/10.33380/2305-2066-2021-10-4-138-146 EDN: YXIKQJВолкова Н. А., Куркин В. А., Правдивцева О. Е., Куркина А. В., Варина Н. Р., Шарова О. В. Исследования по разработке методики количественного анализа побегов боярышника кроваво-красного. Фармация. 2021;70(5):22–26. DOI: https://doi.org/10.29296/25419218-2021-05-03 EDN: JPNEEPVolkova N. A., Kurkin V. A., Pravdivtseva O. E., Kurkina A. V., Varina N. R., Sharova O. V. Investigations for the development of a procedure for the quantitative analysis of redhaw hawthorn (Crataegus sanguinea) shoots. Farmatsiya = Pharmacy. 2021;70(5):22–26. (In Russ.). DOI: https://doi.org/10.29296/25419218-2021-05-03Kurkin V. A., Morozova T. V., Pravdivtseva O. E., Kurkina A. V., Daeva E. D., Kadentsev V. I. Constituents from Leaves of Crataegus sanguinea. Chemistry of Natural Compounds. 2019;55:21–24. DOI: https://doi.org/10.1007/s10600-019-02606-wKurkin V. A., Morozova T. V., Pravdivtseva O. E., Kurkina A. V., Daeva E. D., Kadentsev V. I. Constituents from Leaves of Crataegus sanguinea. Chemistry of Natural Compounds. 2019;55:21–24. DOI: https://doi.org/10.1007/s10600-019-02606-wКуркин В. А., Волкова Н. А., Правдивцева О. Е., Куркина А. В., Трифонова П. В., Дубищев А. В., Агапов А. И., Егорова С. Н. Определение содержания флавоноидов в цветках, листьях и побегах боярышника. Вопросы биологической, медицинской и фармацевтической химии. 2022;25(4):3–9. DOI: https://doi.org/10.29296/25877313-2022-04-01 EDN: JZFAXNKurkin V. A., Volkova N. A., Pravdivtseva O. E., Kurkina A. V., Trifonova P. V., Dubishchev A. V., Agapov A. I., Egorova S. N. Determination of the flavonoid content in flowers, leaves and shoots of Crataegus L. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii = Problems of Biological, Medical and Pharmaceutical Chemistry. 2022;25(4):3–9. (In Russ.). DOI: https://doi.org/10.29296/25877313-2022-04-01Medetbekova A., Kolumbayeva S., Dauletbayeva S. Study of antimutagenic activity of medicinal plant infusions Crataegus sanguinea Pall. family Rosaceae in plant test systems. BIO Web Conferences: International Scientific Forum «Modern Trends in Sustainable Development of Biological Sciences» (IFBioScFU 2024). 2024;100:03011. DOI: https://doi.org/10.1051/bioconf/202410003011Medetbekova A., Kolumbayeva S., Dauletbayeva S. Study of antimutagenic activity of medicinal plant infusions Crataegus sanguinea Pall. family Rosaceae in plant test systems. BIO Web Conferences: International Scientific Forum «Modern Trends in Sustainable Development of Biological Sciences» (IFBioScFU 2024). 2024;100:03011. DOI: https://doi.org/10.1051/bioconf/202410003011Sun J., Gao G., Gao Y. L., Xiong J., Li X., Guo J., Zhang Y. Experimental research on the in vitro antitumor effects of Crataegus sanguinea. Cell Biochemistry and Biophysics. 2013;67:207–213. DOI: https://doi.org/10.1007/s12013-013-9535-6Sun J., Gao G., Gao Y. L., Xiong J., Li X., Guo J., Zhang Y. Experimental research on the in vitro antitumor effects of Crataegus sanguinea. Cell Biochemistry and Biophysics. 2013;67:207–213. DOI: https://doi.org/10.1007/s12013-013-9535-6Куркин В. А., Морозова Т. В., Шайхутдинов И. Х., Лямин А. В., Правдивцева О. Е., Первушкин С. В., Кретова А. А. Сравнительное фитохимическое и микробиологическое исследование жидких экстрактов из плодов боярышника кроваво-красного и боярышника полумягкого. Вопросы биологической, медицинской и фармацевтической химии. 2019;22(4):3–6. DOI: https://doi.org/10.29296/25877313-2019-04-01 EDN: AMWPORKurkin V. A., Morozova T. V., Shaykhutdinov I. Kh., Lyamin A. V., Pravdivtseva O. E., Pervushkin S. V., Kretova A. A. The comparative phytochemical and microbiological study of liquid extracts based on the fruits of the Crataegus sanguinea Pall. and Crataegus submollis Sarg. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii = Problems of Biological, Medical and Pharmaceutical Chemistry. 2019;22(4):3–6. (In Russ.). DOI: https://doi.org/10.29296/25877313-2019-04-01Fedorova D. G., Karpova G. V., Ukenov B. S. The Accumulation of Heavy Metals in the Leaves of Crataegus Sanguinea Pall. (Redhaw Hawthorn) in the Urban Environment (On the Example of Orenburg). IOP Conference Series: Earth and Environmental Science. 2021;670:012030. DOI: https://doi.org/10.1088/1755-1315/670/1/012030Fedorova D. G., Karpova G. V., Ukenov B. S. The Accumulation of Heavy Metals in the Leaves of Crataegus Sanguinea Pall. (Redhaw Hawthorn) in the Urban Environment (On the Example of Orenburg). IOP Conference Series: Earth and Environmental Science. 2021;670:012030. DOI: https://doi.org/10.1088/1755-1315/670/1/012030Blamey M., Grey-Wilson C. Flora of Britain and Northern Europe. Hodder & Stoughton, 1989. 544 p.Blamey M., Grey-Wilson C. Flora of Britain and Northern Europe. Hodder & Stoughton, 1989. 544 p.La Torre C., Loizzo M. R., Frattaruolo L., Plastina P., Grisolia A., Armentano B. et al. Chemical Profile and Bioactivity of Rubus idaeus L. Fruits Grown in Conventional and Aeroponic Systems. Plants. 2024;13(8):1115. DOI: https://doi.org/10.3390/plants13081115La Torre C., Loizzo M. R., Frattaruolo L., Plastina P., Grisolia A., Armentano B. et al. Chemical Profile and Bioactivity of Rubus idaeus L. Fruits Grown in Conventional and Aeroponic Systems. Plants. 2024;13(8):1115. DOI: https://doi.org/10.3390/plants13081115Gao X., Lin F., Li M., Mei Y., Li Y., Bai Y. et al. Prediction of the potential distribution of a raspberry (Rubus idaeus) in China based on MaxEnt model. Scientific Reports. 2024;14:24438. DOI: https://doi.org/10.1038/s41598-024-75559-yGao X., Lin F., Li M., Mei Y., Li Y., Bai Y. et al. Prediction of the potential distribution of a raspberry (Rubus idaeus) in China based on MaxEnt model. Scientific Reports. 2024;14:24438. DOI: https://doi.org/10.1038/s41598-024-75559-yKotuła M., Kapusta-Duch J., Smoleń S., Doskočil I. Phytochemical Composition of the Fruits and Leaves of Raspberries (Rubus idaeus L.) – Conventional vs. Organic and Those Wild Grown. Applied Sciences. 2022;12(22):11783. DOI: https://doi.org/10.3390/app122211783Kotuła M., Kapusta-Duch J., Smoleń S., Doskočil I. Phytochemical Composition of the Fruits and Leaves of Raspberries (Rubus idaeus L.) – Conventional vs. Organic and Those Wild Grown. Applied Sciences. 2022;12(22):11783. DOI: https://doi.org/10.3390/app122211783Krauze-Baranowska M., Głód D., Kula M., Majdan M., Hałasa R., Matkowski A. et al. Chemical composition and biological activity of Rubus idaeus shoots – a traditional herbal remedy of Eastern Europe. BMC Complementary Medicine and Therapies. 2014;14:480. DOI: https://doi.org/10.1186/1472-6882-14-480Krauze-Baranowska M., Głód D., Kula M., Majdan M., Hałasa R., Matkowski A. et al. Chemical composition and biological activity of Rubus idaeus shoots – a traditional herbal remedy of Eastern Europe. BMC Complementary Medicine and Therapies. 2014;14:480. DOI: https://doi.org/10.1186/1472-6882-14-480Ispiryan A., Atkociuniene V., Makstutiene N., Sarkinas A., Salaseviciene A., Urbonaviciene D. et al. Correlation between Antimicrobial Activity Values and Total Phenolic Content/Antioxidant Activity in Rubus idaeus L. Plants. 2024;13(4):504. DOI: https://doi.org/10.3390/plants13040504Ispiryan A., Atkociuniene V., Makstutiene N., Sarkinas A., Salaseviciene A., Urbonaviciene D. et al. Correlation between Antimicrobial Activity Values and Total Phenolic Content/Antioxidant Activity in Rubus idaeus L. Plants. 2024;13(4):504. DOI: https://doi.org/10.3390/plants13040504Krauze-Baranowska M., Majdan M., Hałasa R., Głod D., Kula M., Fecka I., Orzeł A. The antimicrobial activity of fruits from some cultivar varieties of Rubus idaeus and Rubus occidentalis. Food & Function. 2014;5:2536–2541. DOI: https://doi.org/10.1039/C4FO00129JKrauze-Baranowska M., Majdan M., Hałasa R., Głod D., Kula M., Fecka I., Orzeł A. The antimicrobial activity of fruits from some cultivar varieties of Rubus idaeus and Rubus occidentalis. Food & Function. 2014;5:2536–2541. DOI: https://doi.org/10.1039/C4FO00129JČetojević-Simin D. D., Velićanski A. S., Cvetković D. D., Markov S. L., Ćetković G. S., Šaponjac V. T. T. et al. Bioactivity of Meeker and Willamette raspberry (Rubus idaeus L.) pomace extracts. Food chemistry. 2015;166:407–413. DOI: https://doi.org/10.1016/j.foodchem.2014.06.063Četojević-Simin D. D., Velićanski A. S., Cvetković D. D., Markov S. L., Ćetković G. S., Šaponjac V. T. T. et al. Bioactivity of Meeker and Willamette raspberry (Rubus idaeus L.) pomace extracts. Food chemistry. 2015;166:407–413. DOI: https://doi.org/10.1016/j.foodchem.2014.06.063Markov N., Georgiev D., Georgieva M., Bozhanska T., Hristova D., Hristov M. Waste from the summer pruning of berry bushes suitable for feeding beef cattle. Macedonian Journal of Animal Science. 2022;12(1-2):23–28. DOI: https://doi.org/10.54865/mjas22121-2021mMarkov N., Georgiev D., Georgieva M., Bozhanska T., Hristova D., Hristov M. Waste from the summer pruning of berry bushes suitable for feeding beef cattle. Macedonian Journal of Animal Science. 2022;12(1-2):23–28. DOI: https://doi.org/10.54865/mjas22121-2021mLans C., Turner N., Khan T., Brauer G., Boepple W. Ethnoveterinary medicines used for ruminants in British Columbia, Canada. Journal of Ethnobiology and Ethnomedicine. 2007;3:11. DOI: https://doi.org/10.1186/1746-4269-3-11Lans C., Turner N., Khan T., Brauer G., Boepple W. Ethnoveterinary medicines used for ruminants in British Columbia, Canada. Journal of Ethnobiology and Ethnomedicine. 2007;3:11. DOI: https://doi.org/10.1186/1746-4269-3-11Nota G., Svensk M., Barberis D., Frund D., Pagani R., Pittarello M. et al. Foraging behavior of Highland cattle in silvopastoral systems in the Alps. Agroforestry Systems. 2024;98:491–505. DOI: https://doi.org/10.1007/s10457-023-00926-zNota G., Svensk M., Barberis D., Frund D., Pagani R., Pittarello M. et al. Foraging behavior of Highland cattle in silvopastoral systems in the Alps. Agroforestry Systems. 2024;98:491–505. DOI: https://doi.org/10.1007/s10457-023-00926-zАгабабян Ш. М. Кормовые растения сенокосов и пастбищ СССР: в 3 т. Под ред. И. В. Ларина. М.-Л.: Сельхозгиз, 1951. Т. 2: Двудольные (Хлорантовые – Бобовые). С. 486–487.Agababyan Sh. M. Fodder plants of hayfields and pastures of the USSR: in 3 vol. Edited by I. V. Larina. Moscow - Leningrad: Sel'khozgiz, 1951. Vol. 2: Dicotyledons (Chloranthaceae – Legumes). pp. 486–487.Grochowski D. M., Strawa J. W., Granica S., Tomczyk M. Secondary metabolites of Rubus caesius (Rosaceae). Biochemical Systematics and Ecology. 2020;92:104111. DOI: https://doi.org/10.1016/j.bse.2020.104111Grochowski D. M., Strawa J. W., Granica S., Tomczyk M. Secondary metabolites of Rubus caesius (Rosaceae). Biochemical Systematics and Ecology. 2020;92:104111. DOI: https://doi.org/10.1016/j.bse.2020.104111Dudzinska D., Bednarska K., Boncler M., Luzak B., Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433–439. DOI: https://doi.org/10.3109/09537104.2015.1131254Dudzinska D., Bednarska K., Boncler M., Luzak B., Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433–439. DOI: https://doi.org/10.3109/09537104.2015.1131254Dudzinska D., Luzak B., Boncler M., Rywaniak J., Sosnowska D., Podsedek A., Watala C. CD39/NTPDase-1 expression and activity in human umbilical vein endothelial cells are differentially regulated by leaf extracts from Rubus caesius and Rubus idaeus. Cellular and Molecular Biology Letters. 2014;19(3):361–380. DOI: https://doi.org/10.2478/s11658-014-0202-8Dudzinska D., Luzak B., Boncler M., Rywaniak J., Sosnowska D., Podsedek A., Watala C. CD39/NTPDase-1 expression and activity in human umbilical vein endothelial cells are differentially regulated by leaf extracts from Rubus caesius and Rubus idaeus. Cellular and Molecular Biology Letters. 2014;19(3):361–380. DOI: https://doi.org/10.2478/s11658-014-0202-8Hering A., Stefanowicz-Hajduk J., Hałasa R., Olech M., Nowak R., Kosiński P., Ochocka J. R. Polyphenolic Characterization, Antioxidant, Antihyaluronidase and Antimicrobial Activity of Young Leaves and Stem Extracts from Rubus caesius L. Molecules. 2022;27(19):6181. DOI: https://doi.org/10.3390/molecules27196181Hering A., Stefanowicz-Hajduk J., Hałasa R., Olech M., Nowak R., Kosiński P., Ochocka J. R. Polyphenolic Characterization, Antioxidant, Antihyaluronidase and Antimicrobial Activity of Young Leaves and Stem Extracts from Rubus caesius L. Molecules. 2022;27(19):6181. DOI: https://doi.org/10.3390/molecules27196181Schadler V., Dergatschewa S. Rubus caesius L. leaves: Pharmacognostic analysis and the study of hypoglycemic activity. National Journal of Physiology, Pharmacy and Pharmacology. 2017;7(5):501–508. DOI: https://doi.org/10.5455/njppp.2017.7.1234224012017Schadler V., Dergatschewa S. Rubus caesius L. leaves: Pharmacognostic analysis and the study of hypoglycemic activity. National Journal of Physiology, Pharmacy and Pharmacology. 2017;7(5):501–508. DOI: https://doi.org/10.5455/njppp.2017.7.1234224012017Topcu G. D., Koyun N. K., Korkmaz A. The Relationship Standardized Precipitation Evapotranspiration Index (SPEI) and Forage Value of Rubus Species Collected from Türkiye’s Flora. Sustainability. 2024;16(21):9278. DOI: https://doi.org/10.3390/su16219278Topcu G. D., Koyun N. K., Korkmaz A. The Relationship Standardized Precipitation Evapotranspiration Index (SPEI) and Forage Value of Rubus Species Collected from Türkiye’s Flora. Sustainability. 2024;16(21):9278. DOI: https://doi.org/10.3390/su16219278Cosyns E., Degezelle T., Demeulenaere E., Hoffmann M. Feeding ecology of Konik horses and donkeys in Belgian coastal dunes and its implications for nature management. Belgian journal of zoology. 2001;131(S2):111–118. URL: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=812e5da5094aeb40935a06ac170928f7ff7fbc2dCosyns E., Degezelle T., Demeulenaere E., Hoffmann M. Feeding ecology of Konik horses and donkeys in Belgian coastal dunes and its implications for nature management. Belgian journal of zoology. 2001;131(S2):111–118. URL: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=812e5da5094aeb40935a06ac170928f7ff7fbc2dShomurodov H., Khayitov R., Abduraimov O., Maxmudov A., Abduraimov A. Poisonous and harmful plants of pastures in the Kyzylkum desert (Uzbekistan). E3S Web of Conferences. 2024;539:01008. DOI: https://doi.org/10.1051/e3sconf/202453901008Shomurodov H., Khayitov R., Abduraimov O., Maxmudov A., Abduraimov A. Poisonous and harmful plants of pastures in the Kyzylkum desert (Uzbekistan). E3S Web of Conferences. 2024;539:01008. DOI: https://doi.org/10.1051/e3sconf/202453901008Chroho M., Bailly C., Bouissane L. Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species. Planta medica. 2024;90(05):336–352. DOI: https://doi.org/10.1055/a-2269-2113Chroho M., Bailly C., Bouissane L. Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species. Planta medica. 2024;90(05):336–352. DOI: https://doi.org/10.1055/a-2269-2113Dousari A. S., Satarzadeh N., Amirheidari B., Forootanfar H. Medicinal and Therapeutic Properties of Ephedra. Revista Brasileira de Farmacognosia. 2022;32:883–899. DOI: https://doi.org/10.1007/s43450-022-00304-3Dousari A. S., Satarzadeh N., Amirheidari B., Forootanfar H. Medicinal and Therapeutic Properties of Ephedra. Revista Brasileira de Farmacognosia. 2022;32:883–899. DOI: https://doi.org/10.1007/s43450-022-00304-3Ibragic S., Sofic E. Chemical composition of various Ephedra species. Biomolecules Biomed. 2015;15(3):21–27. DOI: https://doi.org/10.17305/bjbms.2015.539Ibragic S., Sofic E. Chemical composition of various Ephedra species. Biomolecules Biomed. 2015;15(3):21–27. DOI: https://doi.org/10.17305/bjbms.2015.539Nurushev M., Nurusheva A., Baibagyssov A. The Role of Climate Change in the Dynamics of the Kazakhstan Population of Saiga (Saiga Tatarica L.). Global Ecology and Biogeography. 2022;5(1):146–153. DOI: https://doi.org/10.17352/gje.000034Nurushev M., Nurusheva A., Baibagyssov A. The Role of Climate Change in the Dynamics of the Kazakhstan Population of Saiga (Saiga Tatarica L.). Global Ecology and Biogeography. 2022;5(1):146–153. DOI: https://doi.org/10.17352/gje.000034Sen Z., Qing C., Keremu A., Shanhui L., Yongjun Z., Defu H. Food patch particularity and forging strategy of reintroduced Przewalski’s horse in North Xinjiang, China. Turkish Journal of Zoology. 2017;41:924–930. DOI: https://doi.org/10.3906/zoo-1509-9Sen Z., Qing C., Keremu A., Shanhui L., Yongjun Z., Defu H. Food patch particularity and forging strategy of reintroduced Przewalski’s horse in North Xinjiang, China. Turkish Journal of Zoology. 2017;41:924–930. DOI: https://doi.org/10.3906/zoo-1509-9Gheibipour M., Ghiasi S. E., Bashtani M., Torbati M. B. M., Motamedi H. The potential of tannin degrading bacteria isolated from rumen of Iranian Urial ram as silage additives. Bioresource Technology Reports. 2022;18:101024. DOI: https://doi.org/10.1016/j.biteb.2022.101024Gheibipour M., Ghiasi S. E., Bashtani M., Torbati M. B. M., Motamedi H. The potential of tannin degrading bacteria isolated from rumen of Iranian Urial ram as silage additives. Bioresource Technology Reports. 2022;18:101024. DOI: https://doi.org/10.1016/j.biteb.2022.101024Тимофеев Н. П. Фитобиотики в мировой практике: виды растений и действующие вещества, эффективность и ограничения, перспективы (обзор). Аграрная наука Евро-Северо-Востока. 2021;22(6):804–825. DOI: https://doi.org/10.30766/2072-9081.2021.22.6.804-825 EDN: SZRHZLTimofeev N. P. Phytobiotics in world practice: plant species and active substances, efficiency and limitations, perspectives (review). Agrarnaya nauka Evro-Severo-Vostoka = Agricultural Science Euro-North-East. 2021;22(6):804–825. (In Russ.). DOI: https://doi.org/10.30766/2072-9081.2021.22.6.804-825Twaij B. M., Hasan M. N. Bioactive secondary metabolites from plant sources: types, synthesis, and their therapeutic uses. International Journal of Plant Biology. 2022;13(1):4–14. DOI: https://doi.org/10.3390/ijpb13010003Twaij B. M., Hasan M. N. Bioactive secondary metabolites from plant sources: types, synthesis, and their therapeutic uses. International Journal of Plant Biology. 2022;13(1):4–14. DOI: https://doi.org/10.3390/ijpb13010003Aljohani A. Botanical Compounds: A Promising Approach to Control Mycobacterium Species of Veterinary and Zoonotic Importance. Pakistan veterinary journal. 2023;43(4):633–642. DOI: http://dx.doi.org/10.29261/pakvetj/2023.107Aljohani A. Botanical Compounds: A Promising Approach to Control Mycobacterium Species of Veterinary and Zoonotic Importance. Pakistan veterinary journal. 2023;43(4):633–642. DOI: http://dx.doi.org/10.29261/pakvetj/2023.107Auezov G. A. M., Pernebekova R., Auezov N. S. M., Uzakovich Z. K., Rakhmonov T., Azamatovna T. K. et al. Comparative analysis of antimicrobial properties of medicinal plants used in veterinary medicine. Caspian journal of environmental sciences. 2024;22:1043–1053. URL: https://cjes.guilan.ac.ir/article_8071_4fb5ab1d48fab6d8f50679265de08179.pdfAuezov G. A. M., Pernebekova R., Auezov N. S. M., Uzakovich Z. K., Rakhmonov T., Azamatovna T. K. et al. Comparative analysis of antimicrobial properties of medicinal plants used in veterinary medicine. Caspian journal of environmental sciences. 2024;22:1043–1053. URL: https://cjes.guilan.ac.ir/article_8071_4fb5ab1d48fab6d8f50679265de08179.pdfFaehnrich B., Franz C., Nemaz P., Kaul H. P. Medicinal plants and their secondary metabolites – State of the art and trends in breeding, analytics and use in feed supplementation – With special focus on German chamomile. Journal of Applied Botany and Food Quality. 2021;94:6174. DOI: https://doi.org/10.5073/JABFQ.2021.094.008Faehnrich B., Franz C., Nemaz P., Kaul H. P. Medicinal plants and their secondary metabolites – State of the art and trends in breeding, analytics and use in feed supplementation – With special focus on German chamomile. Journal of Applied Botany and Food Quality. 2021;94:6174. DOI: https://doi.org/10.5073/JABFQ.2021.094.008Samadov B. S., Jalilova F. S., Jalilov F. S. Analysis of the components of the collection of medicinal plant raw materials of Momordica Charantia L. Scientific progress. 2022;3:49–57. URL: https://cyberleninka.ru/article/n/analysisof-the-components-of-the-collection-of-medicinal-plant-raw-materials-of-momordica-charantia-lSamadov B. S., Jalilova F. S., Jalilov F. S. Analysis of the components of the collection of medicinal plant raw materials of Momordica Charantia L. Scientific progress. 2022;3:49–57. URL: https://cyberleninka.ru/article/n/analysisof-the-components-of-the-collection-of-medicinal-plant-raw-materials-of-momordica-charantia-lCsepregi R., Temesfői V., Das S., Alberti Á., Tóth C. A., Herczeg R. et al. Cytotoxic, antimicrobial, antioxidant properties and effects on cell migration of phenolic compounds of selected transylvanian medicinal plants. Antioxidants. 2020;9(2):166. DOI: https://doi.org/10.3390/antiox9020166Csepregi R., Temesfői V., Das S., Alberti Á., Tóth C. A., Herczeg R. et al. Cytotoxic, antimicrobial, antioxidant properties and effects on cell migration of phenolic compounds of selected transylvanian medicinal plants. Antioxidants. 2020;9(2):166. DOI: https://doi.org/10.3390/antiox9020166Okaiyeto K., Oguntibeju O. O. African herbal medicines: Adverse effects and cytotoxic potentials with different therapeutic applications. International journal of environmental research and public health. 2021;18(11):5988. DOI: https://doi.org/10.3390/ijerph18115988Okaiyeto K., Oguntibeju O. O. African herbal medicines: Adverse effects and cytotoxic potentials with different therapeutic applications. International journal of environmental research and public health. 2021;18(11):5988. DOI: https://doi.org/10.3390/ijerph18115988Nwozo O. S., Effiong E. M., Aja P. M., Awuchi C. G. Antioxidant, phytochemical, and therapeutic properties of medicinal plants: A review. International Journal of Food Properties. 2023;26(1):359–388. DOI: https://doi.org/10.1080/10942912.2022.2157425Nwozo O. S., Effiong E. M., Aja P. M., Awuchi C. G. Antioxidant, phytochemical, and therapeutic properties of medicinal plants: A review. International Journal of Food Properties. 2023;26(1):359–388. DOI: https://doi.org/10.1080/10942912.2022.2157425Faehnrich B., Lukas B., Humer E., Zebeli Q. Phytogenic pigments in animal nutrition: potentials and risks. Journal of the Science of Food and Agriculture. 2016;96(5):1420–1430. DOI: https://doi.org/10.1002/jsfa.7478Faehnrich B., Lukas B., Humer E., Zebeli Q. Phytogenic pigments in animal nutrition: potentials and risks. Journal of the Science of Food and Agriculture. 2016;96(5):1420–1430. DOI: https://doi.org/10.1002/jsfa.7478

The authors declare that there are no conflicts of interest present.