Malignant catarrhal fever: pathogenesis, problems of prevention and control (review)

Malignant catarrhal fever is a non-contagious infectious disease that occurs sporadically in the population of cattle and wild artiodactyls. The source of the causative agent of the disease is wildebeest, sheep, and goats, in which the infectious process is usually asymptomatic. The manifestation of clinical and pathological signs is variable, often characterized by damage to the nervous, respiratory and digestive systems, in the organs and tissues of which signs of lymphocytic and histiocytic vasculitis are noted. Diagnosis of the disease is carried out comprehensively using clinical and histological methods, but the main method is the detection of viral DNA in the material using PCR. However, control and prevention of the disease have a number of difficulties due to insufficient efficiency of diagnostic measures, lack of vaccines and outdated regulatory framework. There are no commercially available kits for diagnosing the disease in Russia. This diagnosis is available to research organizations, where complex research protocols are used. Due to insufficient knowledge of the pathogenesis, attempts to create effective vaccines against malignant catarrhal fever have not yet been successful, which does not allow for the full implementation of preventive measures. Regulatory acts defining approaches to control and elimination of the disease have not been updated for more than 20 years. The complex of these problems significantly distorts the objective epizootic situation on malignant catarrhal fever and contributes to its hidden spread with unclear economic and economic damage.

1. Albini S., Zimmermann W., Neff F., Ehlers B., Häni H., Li H., Hüssy D., Casura C. H., Engels M., Ackermann M. Porcine malignant catarrhal fever: diagnostic findings and first detection of the pathogenic agent in diseased swine in Switzerland. Schweizer Archiv fur Tierheilkunde. 2003;145(2):61–68. DOI: https://doi.org/10.1024/0036-7281.145.2.61

2. Alcaraz A., Warren A., Jackson C., Gold J., McCoy M., Cheong S. H., Kimball S., Sells S., Taus N. S., Divers T., Li H. Naturally occurring sheep-associated malignant catarrhal fever in North American pigs. Journal of Veterinary Diagnostic Investigation. 2009;21(2):250–253. DOI: https://doi.org/10.1177/104063870902100214

3. Carvallo F. R., Uzal F. A., Moore J. D., Jackson K., Nyaoke A. C., Naples L., Davis-Powell J., Stadler C. K., Boren B. A., Cunha C., Li H., Pesavento P. A. Ibex-Associated Malignant Catarrhal Fever in Duikers (Cephalophus Spp). Veterinary pathology. 2020;57(4):577–581. DOI: https://doi.org/10.1177/0300985820918313

4. Myster F., Gong M. J., Javaux J., Suárez N. M., Wilkie G. S., Connelley T., Vanderplasschen A., Davison A. J., Dewals B. G. Alcelaphine herpesvirus 1 genes A7 and A8 regulate viral spread and are essential for malignant catarrhal fever. PLOS Pathogens. 2020;16(3):e1008405. DOI: https://doi.org/10.1371/journal.ppat.1008405

5. Saura-Martinez H., Al-Saadi M., Stewart J. P., Kipar A. Sheep-Associated Malignant Catarrhal Fever: Role of Latent Virus and Macrophages in Vasculitis. Veterinary pathology. 2021;58(2):332–345. DOI: https://doi.org/10.1177/0300985820978310

6. Turk N., Habuš J., Friess M., Zobel R., Grabarević Ž., Barbić L., Štritof Z., Milas Z., Starešina V. Demonstration and quantification of ovine herpesvirus 2 in Croatia - a case report. Veterinarski Arhiv, 2010;80(1):135–143. URL: https://hrcak.srce.hr/en/56050

7. Russell G. C., StewartJ. P., Haig D. M. Malignant catarrhal fever: A review. Veterinary journal. 2009;179(3):324–335. DOI: https://doi.org/10.1016/j.tvjl.2007.11.007

8. Li H., Brooking A., Cunha C. W., Highland M. A., O'Toole D., Knowles D. P., Taus N. S. Experimental induction of malignant catarrhal fever in pigs with ovine herpesvirus 2 by intranasal nebulization. Veterinary microbiology. 2012;159(3-4):485–489. DOI: https://doi.org/10.1016/j.vetmic.2012.04.016

9. Palmer M. V., Thacker T. C., Madison R. J., Koster L. G., Swenson S. L., Li H. Active and latent ovine herpesvirus-2 (OvHV-2) infection in a herd of captive white-tailed deer (Odocoileus virginianus). Journal of comparative pathology. 2013;149(2-3):162–166. DOI: https://doi.org/10.1016/j.jcpa.2013.01.005

10. Decker C., Hanley N., Czajkowski M., Morrison T. A., Keyyu J., Munishi L., Lankester F., Cleaveland S. Predicting uptake of a malignant catarrhal fever vaccine by pastoralists in northern Tanzania: Opportunities for improving livelihoods and ecosystem health. Ecological Economics. 2021;190:107189. DOI: https://doi.org/10.1016/j.ecolecon.2021.107189

11. Garmatz S. L., Irigoyen L. F., Rech R. R., Brown C. C., Zhang J., Barros C. S. L. Malignant catarrhal fever in cattle in Rio Grande do Sul, Brazil: Experimental transmission to cattle and characterization of the etiological agent Pesquisa Veterinária Brasileira. 2004;24(2):93–103. DOI: https://doi.org/10.1590/S0100-736X2004000200009

12. Headley S. A., de Lemos G. A. A., Dall Agnol A. M., Xavier A. A. C., Depes V. C. A., Yasumitsu C. Y., Oliveira T. E. S., Silva L. E., Faccin T. C., Alfieri A. A., Lisboa J. A. N. Ovine gammaherpesvirus 2 infections in cattle without typical manifestations of sheep-associated malignant catarrhal fever and concomitantly infected with bovine coronavirus. Brazilian Journal of Microbiology. 2022;53(1):433–446. DOI: https://doi.org/10.1007/s42770-021-00653-6

13. Headley S. A., Pimentel L. A., Oliveira V. H., Toma H. S., Alfieri A. F., Carvalho A. M., dos Santos M. D., Alfieri A. A. Transplacental Transmission of Ovine Herpesvirus 2 in Cattle with Sheep-associated Malignant Catarrhal Fever. Journal of comparative pathology. 2015;153(4):206–211. DOI: https://doi.org/10.1016/j.jcpa.2015.10.175

14. Jacobsen B., Thies K., von Altrock A., Förster C., König M., Baumgärtner W. Malignant catarrhal fever-like lesions associated with ovine herpesvirus-2 infection in three goats. Veterinary microbiology. 2007;124(3-4):353–357. DOI: https://doi.org/10.1016/j.vetmic.2007.04.037

15. Davison A. J., Eberle R., Ehlers B., Hayward G. S., McGeoch D. J., Minson A. C., Pellett P. E., Roizman B., Studdert M. J., Thiry E. The order Herpesvirales. Archives of virology. 2009;154(1):171–177. DOI: https://doi.org/10.1007/s00705-008-0278-4

16. Simon S., Li H., O'Toole D., Crawford T. B., Oaks J. L. The vascular lesions of a cow and bison with sheepassociated malignant catarrhal fever contain ovine herpesvirus 2-infected CD8(+) T lymphocytes. The Journal of general virology. 2003;84(8):2009–2013. DOI: https://doi.org/10.1099/vir.0.19048-0

17. Cunha C. W., Gailbreath K. L., O'Toole D., Knowles D. P., Schneider D. A., White S. N., Taus N. S., Davies C. J., Davis W. C., Li H. Ovine herpesvirus 2 infection in American bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever. Veterinary microbiology. 2012;159(3-4):307–319. DOI: https://doi.org/10.1016/j.vetmic.2012.04.021

18. Jayawardane G., Russell G. C., Thomson J., Deane D., Cox H., Gatherer D., Ackermann M., Haig D. M., Stewart J. P. A captured viral interleukin 10 gene with cellular exon structure. The Journal of general virology. 2008;89(Pt 10):2447–2455. DOI: https://doi.org/10.1099/vir.0.2008/001743-0

19. Li H., Cunha C. W., Davies C. J., Gailbreath K. L., Knowles D. P., Oaks J. L., Taus N. S. Ovine herpesvirus 2 replicates initially in the lung of experimentally infected sheep. The Journal of general virology. 2008;89(7):1699–1708. DOI: https://doi.org/10.1099/vir.0.2008/000554-0

20. Abd El Rahman S., Ateya A., El-Beskawy M., Wernike K., Hoffmann B., Eschbaumer M. Field Observations and Genetic Characterization of Sheep-Associated Malignant Catarrhal Fever in Egypt. 2018. Veterinary sciences. 2020;7(4):201. DOI: https://doi.org/10.3390/vetsci7040201

21. Costa É. A., Bastianetto E., Vasconcelos A. C., Bomfim M. R. Q., da Fonseca F. G., Gomes A. D., Leite R. C., Resende M. An outbreak of malignant catarrhal fever in Murrah buffaloes in Minas Gerais, Brazil. Pesquisa Veterinária Brasileira. 2009;29(5):395–400. DOI: https://doi.org/10.1590/S0100-736X2009000500006

22. O'Toole D., Li H. The pathology of malignant catarrhal fever, with an emphasis on ovine herpesvirus 2. Veterinary pathology. 2014;51(2):437–452. DOI: https://doi.org/10.1177/0300985813520435

23. Thies K., Jacobsen B., von Altrock A., Foerster Ch., Baumgaertner W., Ganter M. Clinical symptoms in goats with malignant catarrhal fever-like lesions. Tierarztliche Praxis Ausgabe G: Grosstiere – Nutztiere, 2008;36(1):20–26.

24. Li H., Hua Y., Snowder G., Crawford T. B. Levels of ovine herpesvirus 2 DNA in nasal secretions and blood of sheep: implications for transmission. Veterinary microbiology. 2001;79(4):301–310. DOI: https://doi.org/10.1016/s0378-1135(00)00367-9

25. Li H., Cunha C. W., Taus N. S., Knowles D. P. Malignant catarrhal fever: inching toward understanding. Annual review of animal biosciences. 2014;2:209–233. DOI: https://doi.org/10.1146/annurev-animal-022513-114156

26. Pesavento P. A., Cunha C. W., Li H., Jackson K., O'Toole D. In Situ Hybridization for Localization of Ovine Herpesvirus 2, the Agent of Sheep-Associated Malignant Catarrhal Fever, in Formalin-Fixed Tissues. Veterinary pathology. 2019;56(1):78–86. DOI: https://doi.org/10.1177/0300985818798085

27. Zhu H., Huang Q., Hu X., Chu W., Zhang J., Jiang L., Yu X., Zhang X., Cheng S. Caprine herpesvirus 2-associated malignant catarrhal fever of captive sika deer (Cervus nippon) in an intensive management system. BMC veterinary research. 2018;14(1):38. DOI: https://doi.org/10.1186/s12917-018-1365-8

28. Sood R., Hemadri D., Bhatia S. Sheep associated malignant catarrhal fever: an emerging disease of bovids in India. Indian journal of virology. 2013;24(3):321–331. DOI: https://doi.org/10.1007/s13337-013-0163-y