Pathogenetic development patterns of respiratory and gastrointestinal pathologies in calves with proventriculus dysfunction history

An experiment was conducted in the conditions of an industrial complex specializing in the intensive fattening of young cattle, to study the development patterns of respiratory and gastrointestinal pathologies in calves with a history of previous proventriculus dysfunction. The object of the research were calves aged 120 days, which were divided into three groups: control, and two experimental groups - with a difference in using or the absence of phytosorbent. The diet included cereal hay and compound feed (CP 21.5%) according to the norms and regimen of feeding, for animals of this age. It appeared that for calves shortening of the adaptation period to the consumption of a large amount of compound feed had a negative impact on the rumen contractile function and the processes of digestion in it with the formation of a complex of symptoms of frothy tympany and rumen acidosis. After a course of appropriate treatment, the specific symptoms of these pathologies of the rumen disappeared, but the imbalance between the depression of symbiotic and activation of abdominal digestion remained, with the formation of a constant pre-threshold level of local autointoxication. The transfer of animals to the technological diet activated the processes of rumen metabolism and increased biochemical imbalance, which caused the progression of the endogenous intoxication syndrome and vegetative dystonia with a corresponding increase in the risk of developing respiratory and gastrointestinal pathologies. The use of a combined native premix based on the enterosorbent Rigatirin against the background of residual pathological phenomena after proventriculus dysfunctions reduced the level of toxic substances in the rumen, which excluded the generalization of autointoxication with an increase in the functional load on the digestive organs. As a result, the mechanism of pathogenetic integration (predisposition) formation in the body was leveled with a corresponding decrease in the incidence of the lungs, rumen and intestines. As a result, the mechanism of pathogenetic integration (predisposition) formation in the body was leveled, which caused a 6.7-fold decrease in the level of morbidity in animals and a 22.9 % increase in their growth.

1. Kostenko O.V. Russian beef sector: economic analysis and forecast. IOP Conference Series: Earth and Environmental Science. 2021;941:012010. DOI: https://doi.org/10.1088/1755-1315/941/1/012010

2. Manzhurina O. A., Parkhomenko Yu. S., Perepelkina I. S., Semenova E. V., Kopytina K. O., Rozhkova I. N., Dmitrieva N. A. Etiological structure of pneumoenteritises in calves on cattle breeding farms in the central region of the Russian Federation. Veterinarnyy farmakologicheskiy vestnik = Bulletin of veterinary pharmacology. 2020;(1(10)):96-100. (In Russ.). DOI: https://doi.org/10.17238/issn2541-8203.2020.1.96

3. Wilson D. J., Habing G., Winder C. B., Renaud D. L. A scoping review of neonatal calf diarrhea case definitions. Preventive Veterinary Medicine. 2023;211:105818. DOI: https://doi.org/10.1016/j.prevetmed.2022.105818

4. Booker C. W., Lubbers B. V. Bovine Respiratory Disease Treatment Failure: Impact and Potential Causes. Veterinary Clinics of North America: Food Animal Practice. 2020;36(2):487-496. DOI: https://doi.org/10.1016/j.cvfa.2020.03.007

5. Smith R. A., Step D. L., Woolums A. R. Bovine Respiratory Disease: Looking Back and Looking Forward, What Do We See? Veterinary Clinics of North America: Food Animal Practice. 2020;36(2):239-251. DOI: https://doi.org/10.1016/j.cvfa.2020.03.009

6. Zhukov M., Alekhin Yu., Kalyuzhny I., Dorozhkin V., Stekolnikov A. Reasons for cattle retirement on feeding farms. BIO Web of Conferences. International Scientific-Practical Conference “Agriculture and Food Security: Technology, Innovation, Markets, Human Resources” (FIES 2019). 2020;17:0098. DOI https://doi.org/10.1051/bioconf/20201700098

7. Pažout V., Strakova E., Suchý P., Hygiene A. Effect of intensive fattening of bulls based on a high-grain diet on growth intensity and biochemical and acid-base parameters of blood. Czech Journal of Animal Science. 2005;50(8):355-361. DOI: http://dx.doi.org/10.17221/4177-CJAS

8. Magrin L., Gottardo F., Contiero B., Cozzi G. Association between gastrointestinal tract, claw disorders, on-farm mortality and feeding management in veal calves. Italian Journal of Animal Science. 2021;20(1):6-13. DOI: https://doi.org/10.1080/1828051X.2020.1863868

9. Popova O. S., Baryshev V. A. Evaluation of toxicity of rigatirin and phytosorption complex with chitosan on laboratory animals. Innovative activity of science and education in agro-industrial production: Proceedings of International. scientific and practical. conf. Kursk: KGSKhA im. I. I. Ivanova, 2019. С. 324-328. URL: https://elibrary.ru/item.asp?id=39223608&ysclid=li1bu44idh968648866

10. Popova O. S., Baryshev V. A. Study of the influence of Rigatirin on the biochemical status of lacting cows. Mezhdunarodnyy veterinarnyy vestnik. 2019;(3):40-44. (In Russ.). URL: https://elibrary.ru/item.asp?id=41138484&ysclid=li1bwu305w942962885

11. Alekhin Yu. N., Zhukov M. S. Method for diagnosing cicatricial digestion disorders in ruminants: Patent RF, no. №2565412. 2015. URL: https://www1.fips.ru/registers-docview/fips_servlet?DB=RUPAT&rn=4993&DocNumber=2565412&TypeFile=pdf

12. Dias Batista L. F., Norris A. B., Adams J. M., Hairgrove T. B., Tedeschi L. O. Technical Note: The comparison of pH and redox potential in different locations in the reticulo-rumen of growing beef steers supplemented with different levels of quebracho extract. Journal of Animal Science. 2021;99(10):skab260. DOI: https://doi.org/10.1093/jas/skab260

13. Srivastava R., Singh P., Tiwari S., Mishra D. B., Kumar G. Sub-acute ruminal acidosis: Understanding the pathophysiology and management with exogenous buffers. Journal of Entomology and Zoology Studies. 2021;9(2):593-599. DOI: https://doi.org/10.22271/j.ento.2021.v9.i2i.8537

14. Nagaraja T. G. Ruminal microbes, microbial products, and systemic inflammation. Journal of Animal Science. 2016;94(suppl_5):90-94. DOI: https://doi.org/10.2527/jam2016-0186

15. Mizera L., Boehm K., Duckheim M., Groga-Bada P., Gawaz M., Zuern Ch. S., Eick Ch. Autonomic nervous system activity for risk stratification of emergency patients with pneumonia. The Journal of Emergency Medicine. 2018;55:472-480. DOI: https://doi.org/10.1016/j.jemermed.2018.06.016

16. Zhukov M. S., Alekhin Yu. N., Morgunova V. I., Nikonenko G. V. Kriterii otsenki tyazhesti techeniya bronkhopnevmonii u telyat. Veterinarnyy farmakologicheskiy vestnik = Bulletin of veterinary pharmacology. 2022;(2(19)):103-122. (In Russ.). DOI: https://doi.org/10.17238/issn2541-8203.2022.2.103